![]() ![]() Stem cell-based tissue engineering with silk biomaterials. Wang Y, Kim HJ, Vunjak-Novakovic G, Kaplan DL. Treatments of meniscus lesions of the knee: current concepts and future perspectives. 2018 10:37820.Ĭengiz IF, Pereira H, Espregueira-Mendes J, Oliveira JM, Reis RL. Exploitation of cationic silica nanoparticles for bioprinting of large-scale constructs with high printing fidelity. Lee M, Bae K, Guillon P, Chang J, Arlov Ø, Zenobi-Wong M. 3D cartilage regeneration with certain shape and mechanical strength based on engineered cartilage gel and decalcified bone matrix. 2018 22:26.Ĭi Z, Zhang Y, Wang Y, Wu GY, Hou MJ, Zhang PL, Jia LT, Bai BS, Cao YL, Liu Y, Zhou GD. Micro-CT-a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results. Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size. 2021 25:2.īuenzli PR, Lanaro M, Wong CS, McLaughlin MP, Allenby MC, Woodruff MA, Simpson MJ. Bioceramic hydroxyapatite-based scaffold with a porous structure using honeycomb as a natural polymeric Porogen for bone tissue engineering. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Miller JS, Stevens KR, Yang MT, Baker BM, Nguyen DH, Cohen DM, Toro E, Chen AA, Galie PA, Yu X, Chaturvedi R, Bhatia SN, Chen CS. High-density seeding of myocyte cells for cardiac tissue engineering. Radisic M, Euloth M, Yang L, Langer R, Freed LE, Vunjak-Novakovic G. On-site alginate gelation for enhanced cell proliferation and uniform distribution in porous scaffolds. Li Z, Gunn J, Chen MH, Cooper A, Zhang M. Bioprinting and regeneration of auricular cartilage using a bioactive bioink based on microporous photocrosslinkable acellular cartilage matrix. Jia LT, Hua YJ, Zeng JS, Liu WS, Wang D, Zhou GD, Liu X, Jiang HY. High strength HA-PEG/NAGA-Gelma double network hydrogel for annulus fibrosus rupture repair. Zhang YC, Gao HC, Luo HT, Chen DF, Zhou ZY, Cao XD. A photo-crosslinked proteinogenic hydrogel enabling self-recruitment of endogenous TGF-β1 for cartilage regeneration. Ju XJ, Liu XZ, Zhang Y, Chen X, Chen MM, Shen HS, Feng YH, Liu JS, Wang M, Shi Q. Architected fibrous scaffolds for engineering anisotropic tissues. Reid JA, Dwyer KD, Schmitt PR, Soepriatna AH, Coulombe KL, Callanan A. Articular cartilage and osteochondral tissue engineering techniques: recent advances and challenges. Autotherapies: enhancing endogenous healing and regeneration. ![]() Lumelsky N, O’Hayre M, Chander P, Shum L, Somerman MJ. ![]() Based on the design concept of dual-network Fr-SF-SEAs scaffolds, homogenous and mature cartilage was successfully regenerated with precise and complicated shapes, which hopefully provides a platform strategy for tissue engineering for various cartilage defect repairs. The established novel cell inoculation method is highly versatile and can be readily applied to various cells. Importantly, the SF-SEAs preparation showed valuable universality in combining chemicals with other bioactive materials or drugs with reactive groups to construct microenvironment bionic scaffolds. Furthermore, the regenerated cartilage of the Fr-SF-SEAs scaffold withstood a dynamic pressure environment after subcutaneous implantation and maintained its precise original structure, ultimately achieving human-scale ear-shaped cartilage regeneration. The Fr-SF-SEAs exhibited the desirable synergistic properties of a honeycomb structure, hygroscopicity and elasticity, which allowed them to undergo an unconventional cyclic compression inoculation method to significantly promote cell diffusion and achieve a uniform cell distribution at a high-density. In this study, silk fibroin was integrated with silk short fibers with a physical and chemical double-crosslinking network to fabricate fiber-reinforced silk fibroin super elastic absorbent sponges (Fr-SF-SEAs). However, due to insufficient cell infiltration and inadequate mechanical properties, engineered tissue made from porous scaffolds may have an inconsistent cellular composition and a poor shape retainability, which seriously hinders their further clinical application. The ideal engineered tissue should have the desired structure and functional properties suitable for uniform cell distribution and stable shape fidelity in the full period of in vitro culture and in vivo implantation. Tissue engineering provides a promising approach for regenerative medicine. ![]()
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