Future studies should devise a new model for estimation of baseline Cr that is validated in this population. Estimated age-based GFR was 95.9±5.8 mL⋅min −1 compared to GFR based on measured Cr and MDRD of 86.1☑4.6 ( P<0.001).Įstimated values of GFR and Cr by standard age-based values and MDRD equation were significantly inaccurate, which would overinflate the incidence of acute kidney injury. The mean measured Cr was 0.99☐.17, which was 11% higher than an estimated Cr of 0.88☐.14 ( P<0.01). Runners had prerace measured baseline Cr compared to estimated values through age-based estimated GFR and back calculation of Cr through the MDRD equation.įorty-eight participants (27% female, age 39☑0 y) had Cr values analyzed. However, the accuracy of this practice in a cohort of healthy athletes is unknown.Ī prospective analysis of the first 40-km (25-mi) stage of 6-stage 250-km (155-mi) multistage ultramarathons in the Sahara, Namibia, Atacama, and Gobi Deserts. Values are estimated through an age-based formula of GFR and the modification of diet in renal disease (MDRD) equation. Multiple studies have examined acute kidney injury through estimated baseline creatinine (Cr) and glomerular filtration rate (GFR). Ultramarathon running is increasing in popularity worldwide, as is the growing body of research on these athletes. Moreover, the compactness of the analyzer and the requirement for only small volumes of whole blood will make it a valuable diagnostic tool in point of care settings. Our study has shown the i-STAT ™ system to be reliable, robust, and simple to operate. The standard error about the regression line ( S y x) ranged from 0.017 for hematocrit to 2.262 for chloride in the assay of venous blood, whereas in the assay of capillary blood the S y x ranged from 0.018 for hematocrit to 0.755 for glucose.Ĭonclusions: The analytical performance of the i-STAT was deemed acceptable by calculation of total error and comparison with published performance standards. Linear regression analysis revealed minimal systematic errors. Total imprecision as expressed by the coefficient of variation (CV) was less than 3.5% for all analytes at both high and low concentrations except for a low concentration of urea where a CV of 9.4% was obtained. Results: Linearity was obtained over the clinically relevant range for all analytes. The accuracy of the i-STAT system was judged by assay of patient specimens obtained both by venipuncture and fingerprick and correlated with the Kodak Ektachem 700XR and the microhematocrit methods. Methods: Linearity and imprecision in hematocrit measurement were assessed using whole blood, while that for the other analytes were evaluated with aqueous solutions. Objective: To evaluate the analytical performance of the i-STAT ™ system, which is designed for point of care testing and employs a hand-held chemistry analyzer and disposable cartridges, which in the configuration tested, are capable of measuring sodium, potassium, chloride, urea, glucose, and hematocrit in approximately 65 μL of blood in 90 s.
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